AltPep develops early disease-modifying treatments and detection tools for amyloid diseases by targeting toxic soluble oligomers. The company's platform uses custom-designed peptides to bind selectively to alpha-sheet structures, a molecular trigger identified through decades of research by the Daggett Research Group. Their lead program focuses on Alzheimer’s disease with a preclinical compound, SOBIN-AD, showing increased clearance of Aβ toxic oligomers and inhibition of plaque formation.
Detect amyloid diseases via blood tests before symptoms appear; Neutralize toxic soluble oligomers in Alzheimer’s patients; Monitor disease progression using blood-based diagnostics; Develop treatments for Parkinson’s and other amyloid diseases
Presented new preclinical data at AAIC 2025; Lead compound SOBIN-AD shows increased clearance of Aβ toxic oligomers; Founded by Valerie Daggett, PhD, Endowed Professor of Bioengineering at UW; Decades of research culminated in alpha-sheet discovery